Ungabhema ibhodwe elivamile futhi ube nama-gummies e-CBD. Izokwenza kusebenze umphumela obizwa nge-'Entourage Effect', okwandisa izinzuzo ze-CBD gummies.
I-CBD (cannabidiol) ne-THC (tetrahydrocannabinol) zingama-cannabinoids amabili atholakala ezitshalweni zensangu. Akhiqizwa ngamanani alinganayo nge-cannabis ne-hemp. Ngakolunye uhlangothi, insangu inephesenti elikhulu le-THC kuyilapho i-Hemp inephesenti elikhulu le-CBD kunensangu.I-CBD ne-THC zinenani elifanayo lama-athomu e-carbon, ama-athomu e-hydrogen angamashumi amathathu, nama-athomu amabili omoya-mpilo. Umehluko kungenxa yokuthi awanakho ukwakheka kwamakhemikhali okufanayo ngakho-ke amuncwa umzimba njengama-molecule ahlukene. Lawa makhemikhali asebenzisana nama-neurotransmitters ebuchosheni futhi athinte imizwa, ubuhlungu, ukulala, nenkumbulo.
Kuso sonke lesi sihloko, sizocubungula izinsini ze-CBD njenge-CBD kanye nebhodwe elivamile noma insangu (insangu) njenge-THC, ngoba lokho kuyisici esiyinhloko. Nakuba kokubili i-CBD ne-THC zitholakala ku-cannabis, zombili zihluke kakhulu. Manje, ake sifunde kabanzi nge-CBD ne-THC.
Yini i-CBD?
I-CBD iyikhemikhali eyenzeka ngokwemvelo etholakala embalini enenhlaka yensangu, isitshalo esinomlando omude njengekhambi lokwelapha elaqala ezinkulungwaneni zeminyaka. Namuhla, ososayensi nodokotela emhlabeni wonke bayahlola futhi baqinisekisa izinzuzo zokwelapha ze-CBD. Kuyikhemikhali engaluthayo futhi engeyona enobuthi engaphezu kwekhulu "ye-phytocannabinoids" etholakala ku-cannabis kuphela, ehlinzeka isitshalo ngephrofayili yaso eqinile yezokwelapha.
I-CBD ixhumene eduze nenye i-phytocannabinoid ebalulekile esebenzayo kwezokwelapha: i-THC, isakhi se-psychoactive ye-cannabis. Lezi yizingxenye ezimbili ze-cannabis obekuyisihloko sophenyo olukhulu lwesayensi. I-CBD kanye ne-THC zombili zinezakhiwo zokwelapha ezinkulu. Kodwa-ke, ngokungafani ne-THC, i-CBD ayibangeli ukozela noma ukudakwa. Lokho kungenxa yokuthi i-CBD ne-THC zisebenza ngendlela ehlukile ebuchosheni nakwamanye ama-receptors ahlukahlukene.
I-CBD inganciphisa noma isuse imithelela edakayo ye-THC, kuye ngenani elithathiwe. Abantu abaningi bafuna izinzuzo zezempilo ze-cannabis ngaphandle kokuthola "okuphezulu" - noma okungenani izinga elincishisiwe lokudakwa. Amandla okwelapha e-CBD, imvelo engadaki, kanye nokuphatha kalula njengowoyela we-CBD kwenza kube ukukhetha okukhangayo kokwelapha kubantu abamadolonzima ukuzama i-cannabis okokuqala ngqa.
Iyini iTHC?
I-THC, evame ukubizwa nge-tetrahydrocannabinol, iyisithako se-psychoactive ku-cannabis esikwenza uzizwe "uphakeme." Itholakala kokubili insangu kanye ne-hemp.Ngakolunye uhlangothi, iTHC inesakhiwo esifana nesakhemikhali yemvelo i-anandamide (ekhiqizwa ebuchosheni), ishintsha umsebenzi wokuxhumana. Ngenxa yalokhu, kunokuba ukuxhumana kobuchopho okuvamile okwenzeka ngama-neuron, i-molecule ye-THC inamathela kuma-neurons futhi iguqule inqubo.
Ngokusho kweNational Institute on Drug Abuse (NIDA), kukhonjisiwe ukuthi iTHC ithinta izinto ezinjengokucubungula umcabango, inkumbulo, ukuzijabulisa, ukunaka, ukusebenzisana, kanye nombono wezinzwa nowesikhashana. Ngalezi zizathu, ukuzibandakanya emisebenzini efana nokusebenzisa izinto ezisindayo noma ukushayela ungaphansi kwe-THC kungaba yingozi.
Noma kunjalo, izincazelo ezingezinhle ezihlotshaniswa ne-THC (ikakhulukazi mayelana nokusetshenziswa kwensangu) kungenzeka zingameli isithombe esigcwele. Isibonelo, i-THC ifakazelwe ukuthi ihlinzeka ngezinzuzo ezimbalwa zezempilo, okuhlanganisa ukwelapha ukudangala, ukuphazamiseka kwengcindezi yangemva kwenhlekelele (PTSD), isithuthwane, ngisho nezinkinga zokudla.
Ungakwazi yini Ukusebenzisa i-CBD futhi wenze i-Pot?
Eqinisweni ungasebenzisa insangu (yenza ibhodwe) ngenkathi usebenzisa I-CBD gummies . Izodala umphumela obizwa nge-"Entourage Effect."
I-Entourage Effect kwenzeka lapho i-CBD ihlanganiswa ne-THC (kuhlanganise namanye ama-cannabinoids nama-phytosterols). Lokhu kusho ukuthi amakhemikhali asebenza ngokubambisana futhi anamandla kakhulu uma ehlangene kunalapho esetshenziswa ewodwa.
I-CBD futhi ingamelana nengxenye yesici se-THC se-psychoactive, okusho ukuthi ukuphakama kuzoncipha, kulinganiseke, futhi kunempilo. I-CBD futhi iyisicindezeli sesifiso sokudla, esingakusiza ugweme ukudla okulula uma kuyinkinga. Sazise kabanzi mayelana nomphumela we-Entourage.
Umphumela Wokuhlangana
Lona umbono wokuthi wonke amakhemikhali aku-cannabis asebenza ngokuvumelana. Ngakho-ke, uma kusetshenziswe ndawonye, umphumela onamandla kakhulu uyadalwa kunesamba sazo ngasinye.
Izinzuzo zokwelapha zezingxenye ezihlukahlukene ze-cannabis zingashintshwa noma zikhuphuke uma zihlanganiswa ekwakhiweni okukodwa. Ngaphezu kwalokho, izinto ezithandwayo kanye namandla okusebenza kwengqondo ezimpahla zingashintshwa, okuholele emikhiqizweni ehlukahlukene enezakhiwo ezahlukene.
Ngokusho kwabasekeli bayo, amandla eqembu lomphumela we-entourage angase anikeze izici eziphuthumayo, ezifana nokukhulula ubuhlungu, obungeke butholakale ku-THC ehlanzekile noma i-CBD.
Abantu abaningi abasebenza eduze ne-cannabis bacabanga ukuthi umphumela we-entourage ungathuthukisa kakhulu ukusetshenziswa kwezokwelapha kwe-THC ne-CBD, noma ngokwandisa imiphumela yabo eyaziwa kakade noma ngokwandisa ububanzi bezinto ezingase zisetshenziswe zokwelapha.
Amandla amakhemikhali e-cannabis okunamathisela kuma-endocannabinoid receptors akhona ngokwemvelo ebuchosheni nakuwo wonke isimiso sezinzwa esimaphakathi anesibopho sezinzuzo zawo zokwelapha. Yize uhlelo lomuntu lwe-endocannabinoid luhloselwe ukuxhumana nama-cannabinoids angapheli akhiqizwa umzimba, amakhemikhali atholwe ezitshalweni ze-cannabis angabopha nalawa ma-receptors.
Uma sithatha insangu yezokwelapha yekhwalithi ephezulu, izinzuzo zezempilo ziningi. Umthelela we-entourage ungaba esinye sezici ezinomthelela ekusebenzeni kahle kwensangu njengokwelashwa.
I-Phytocannabinoids iyinhlanganisela etholakala ezitshalweni ze-cannabis ezinezinhlobo ezingaphezu kwe-120 ezihlukene. Lawa ma-phytocannabinoids athinta uhlelo lwe-endocannabinoid, olunesibopho sokugcina ibhalansi emzimbeni wakho.
Njengoba sekushiwo, ezinye izifundo zibonisa ukuthi ukuthatha i-CBD ne-THC ndawonye (kanye nezinye izakhi zamakhemikhali ezincane ezitholakala esitshalweni sensangu esaziwa ngokuthi i-terpenes noma i-terpenoids) kungaba yinzuzo kakhulu kunokuthatha ngokuhlukana.
Uzizwa Kanjani I-Entourage Effect?
I-CBD isebenzisana ne-CB1 kanye ne-CB2 receptors kodwa ayibophezeli kunoma iyiphi yalawa ma-receptors. Lokhu akuvamile phakathi kwama-cannabinoids, njengoba uzobona ngezansi. Ngawoyela we-CBD we-spectrum egcwele noma obanzi, udla izinhlobo ezihlukahlukene ze-cannabinoids ezibophezela kuma-receptors ohlelweni lwezinzwa olumaphakathi kanye nesistimu yezinzwa ezungezile, okuholela ezinzuzweni ezihlukahlukene zezempilo. Umphumela we-entourage ungacatshangwa njengokwandiswa kohlelo lwakho lwe-endocannabinoid okwenzeka ngenxa yokusetshenziswa kwama-cannabinoids amaningana.Uma uthenga ama-gummies e-CBD, uzothola ukuthi afaka phakathi izinhlobonhlobo zama-cannabinoids kune-CBD kuphela. Lokhu akwenzekanga nje kodwa kwakhiwe ngobuhlakani.
Ucwaningo kuze kube manje seluthole izimo ezithile ezizuzisa abasebenzisi kakhulu ngenhlanganisela ye-CBD, iTHC, namanye ama-terpenes. Ngokwesibonelo, ngokocwaningo olwanyatheliswa ku- I-British Journal of Pharmacology , inhlanganisela efanele ingazuzisa izinhlungu, isithuthwane, ukukhathazeka, izifo zesikhunta, ngisho nezinhlobo ezithile zomdlavuza.
Ukunakwa okwengeziwe kufanele kunikezwe iqiniso lokuthi i-CBD inganciphisa imiphumela ye-psychoactive ye-THC.
Izinzuzo ze-CBD Gummies
I-CBD iyasiza ku- ukwelashwa kobuhlungu , ukukhathazeka, ukudangala, kanye nokuvuvukala Ama-gummies e-CBD afakwe uwoyela angasiza kakhulu ukuphazamiseka kokulala . I-FDA igunyaze ukusetshenziswa komuthi we-CBD (Epidiolex) ukwelapha isithuthwane.
I-CBD gummies ingaba wusizo ekwelapheni ukukhathazeka, ukungezwani, nobuhlungu. Ngaphezu kwalokho, ubufakazi bukhomba ukuthi ama-gummies e-CBD akhiqizwa ku-hemp angaba nomthelela omuhle ezinkingeni zempilo ezahlukahlukene. Ama-gummies anamandla ahlukahlukene kanye nokugxila kwe-THC ayatholakala ku-inthanethi.
Udokotela kufanele abonane nodokotela ngaphambi kokusebenzisa imikhiqizo ye-CBD uma umuntu ephuza imithi, ekhulelwe/emhlengikazi, noma enesifo esimphethe kabi.
Kufanele wazi ukuthi i-CBD iyikhemikhali ebabayo okusho ukuthi amaswidi amaningi afaka amanani abalulekile kashukela owengeziwe ukuvala ukunambitheka okunzima komuthi.
Izinzuzo Zensangu (Imbiza)
Ngokuhamba kweminyaka, ucwaningo luye lwaveza okutholakele okubonisa ukuthi insangu ingaba nenzuzo ekwelapheni izifo ezithile, okuhlanganisa nomdlavuza.Ngokusho kokubuyekezwa, insangu iyasiza ekwelapheni ubuhlungu obungapheli kanye nokulawula ukukhathazeka komphakathi. Ngaphezu kwalokho, kukhonjisiwe ukuthi ama-cannabinoids alawulwa ngomlomo asiza ekudambiseni isicanucanu nokuhlanza okuhambisana nokwelashwa ngamakhemikhali. Ezinye izifundo ezincane zithole ukuthi insangu ingase futhi iphumelele ekudambiseni izimpawu ezifanayo.
Isiphetho
Umphumela we-entourage usathathwa njenge-hypothesis. Kusenocwaningo oluningi oludingekayo esitshalweni se-cannabis kanye nokwakheka kwaso kwamakhemikhali ngaphambi kokunquma uhla olugcwele lwezinzuzo zaso zokwelapha ezingaba khona. Njalo thintana nodokotela ngaphambi kokuthatha noma yimuphi umuthi ukuze uqiniseke ukuthi usetshenziswa ngendlela ephephile.